Taxanes Versus Vinorelbine and 5-Fluorourocil as a first Line Therapy in Metastatic Breast Cancer.
نویسندگان
چکیده
منابع مشابه
Epirubicin-vinorelbine intravenous combination followed by oral vinorelbine as first-line treatment in metastatic breast cancer.
Epirubicin and vinorelbine are considered active drugs in metastatic breast cancer. The optimal duration of a chemotherapy regimen for metastatic breast cancer patients is still unknown. Nevertheless, epirubicin has a dose-limiting cardiotoxicity. Vinorelbine is also available as oral formulation. In a multicenter phase II study, we analyzed the feasibility and the efficacy of a maximum of six ...
متن کاملTaxanes as a first-line systemic treatment in metastatic breast cancer.
First-line treatment of metastatic breast cancer (MBC) is an important therapeutic setting. Effective treatment of MBC in the initial setting can extend a patient's life and provide significant improvements in quality of life. The taxanes paclitaxel, docetaxel, and nab-paclitaxel have been investigated as first-line therapy for MBC requiring chemotherapy in numerous trials. Results from these t...
متن کاملComparative Study of Vinorelbine Monotherapy Versus Vinorelbine- Cisplatin in Metastatic Breast Cancer Patients Previously Treated with Anthracyclines and Taxanes
Background: There are few proved standards of care in metastatic breast cancer patients previously treated with anthracyclines and taxanes. This prospective randomized study was carried out to compare vinorelbine/cisplatin and vinorelbine single agent regarding efficacy, toxicity, PFS and overall survival after progression on anthracyclin and/or taxanes in patients with metastatic cancer breast...
متن کاملVinorelbine, methotrexate and fluorouracil (VMF) as first-line therapy in metastatic breast cancer: a randomized phase II trial.
BACKGROUND The purpose of this study was to determine the best tolerated and efficacious dose of vinorelbine given once or twice in 3-week cycles in combination with methotrexate and fluorouracil (VMF). PATIENTS AND METHODS Vinorelbine 40 mg/m(2) was given as follows: 20 mg/m(2) on days 1 and 8 (group 1); 30 mg/m(2) on day 1 and 10 mg/m(2) on day 8 (group 2); or 40 mg/m(2) on day 1 (not exeed...
متن کاملTaxanes alone or in combination with anthracyclines as first-line therapy of patients with metastatic breast cancer.
PURPOSE Taxanes (paclitaxel or docetaxel) have been sequenced or combined with anthracyclines (doxorubicin or epirubicin) for the first-line treatment of advanced breast cancer. This meta-analysis uses data from all relevant trials to detect any advantages of taxanes in terms of tumor response, progression-free survival (PFS), and survival. PATIENTS AND METHODS Individual patient data were co...
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ژورنال
عنوان ژورنال: Research in Oncology
سال: 2011
ISSN: 2357-0695
DOI: 10.21608/resoncol.2011.432